Zsigeri fájdalom, nocebo-hatások, placebo-analgézia

Összefoglaló. A belső szervek működési zavarai gyakran származnak viselkedési, lelki vagy pszichoszociális okokból, amelyeknek nem mindig vagyunk tudatában. Minthogy ebben a folyamatban egy bonyolult neuronális hálózat játssza fő szerepet, ezeknek zavaroknak diagnózisa és terápiája számos tényező manipulálását igényli. funkcionális gyomor-bélhuzam rendellenességek (FGID), például az irritábilisbél-szindróma (IBS), jellemző példái ennek: olyan zavarokról van szó, amelyek mögött jól detektálható szervi biokémiai elváltozásokat találnak. Ilyenkor szükségesnek tűnik komplex megközelítés, amely többféle szakember együttműködését kívánja meg. Szerepe lehet pszichés életmód terápiának, gyógyszeres fizikai kezelésnek is, – ahogy cikkben megmutatjuk placebo-terápiának is. Summary. Functional disorders of the internal organs frequently are results behavioral, mental or psycho-social dysfunctions, although we usually not conscious about it. typical example isirritable bowel syndrome characteristic functional gastro-intestinal disorder which is regularly accompanied by abdominal pain and irregular intestinal motility defecation. It has been shown that this cannot be due to single factor, nor it result local cause. Recently researchers have proven malfunction complicated neuronal network, including several brain sites, may responsible for IBS. believed now IBS consequence nocebo-effects. source visceral discomfort, difficult identify. Main factors stimuli originating from tract, passing through spinal cord reaching structures, cortical sub-cortical sites. some structures become thicker while others thinner as lasting pain, resulting in altered top-down effects on organs. Several hormones accompany these processes network activity. Recent research revealed requires complex approach, optimally provided therapeutic team physicians, psychologist/psychiatrist, associates, even patient himself/herself. They apply suggest medicines, physiotherapy, lifestyle modifications, alimentary changes etc. An important feature nocebo-effect plays an role generation IBS, thus one think opposite phenomenon, placebo-effect could used process. And really, placebo-analgesia method therapy Placebo-analgesia affects processes, processing, release hormones, endogenous opioids, primary pain-decreasing factors. pain-modification system exists can affected activated counteracting nocebo-effects improving condition individual. The placebo phenomenon interesting itself, too. By now, major question existence but mechanisms behind Recently, brain-mapping techniques gained their research, lot new information proves (as well nocebo-effect) involves different cortex limbic system, respectively.P widely clinical practice, first all reference treatment when drugs medicines tested effectivity. There numerous ethical problems area, recently, example, testing Covid-19 vaccines. main problem whether legal keep non-treated population, placebo-group should treated immediately after trial ends, members get adequate information.